GDF5 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comGDF5 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > GDF5(Gene name) > Human

GDF5 (Gene name),

Growth/differentiation factor 5 (Protein name ), GDF5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GDF5(CDMP1);

Protein name:

Growth/differentiation factor 5(GDF-5);

Alternative:

Radotermin;Cartilage-derived morphogenetic protein 1(CDMP-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked.

Function:

Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

501

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

501:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:8200

SMR:

P43026

Pfam:

PF00019

UniGene:

Hs.1573

MIM:

112600

MIM:

112500

String:

P43026

STRING:

9606.ENSP00000363489

Uniprot:

P43026

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ELISA Kit for Human GDF-5

Cat.:

E0550m

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MSDS:

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Packing:

96T

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ELISA Kit for Human GDF-5

Cat.:

E0550h

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MSDS:

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Packing:

96T

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CLIA Kit for Human GDF-5

Cat.:

U0550h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human GDF-5

Cat.:

U0550m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human GDF-5

Cat.:

P0550Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human GDF-5

Cat.:

P0550Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human GDF-5

Protein for Human GDF-5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Cloning and expression of recombinant human growth/differentiation factor 5."
Hoetten G. , Neidhardt H. , Jacobowsky B. , Pohl J.
Biochem. Biophys. Res. Commun.204:646-652(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
2.

"Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development."
Chang S. , Hoang B. , Thomas J.T. , Vukicevic S. , Luyten F.P. , Ryba N.J.P. , Kozak C.A. , Reddi A.H. , Moos M.
J. Biol. Chem.269:28227-28234(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-276
tissue: Articular cartilage.
3.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-276
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
6.

"A CD14-independent LPS receptor cluster."
Triantafilou K. , Triantafilou M. , Dedrick R.L.
Nat. Immunol.2:338-345(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION AS LPS RECEPTOR;INTERACTION WITH CXCR4; HSP90AA1 AND HSPA8;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes."
Bai X. , Xiao Z. , Pan Y. , Hu J. , Pohl J. , Wen J. , Li L.
Biochem. Biophys. Res. Commun.325:453-460(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"A novel mutation in CDMP1 causes brachydactyly type C with 'angel-shaped phalanx'. A genotype-phenotype correlation in the mutational spectrum."
Gutierrez-Amavizca B.E. , Brambila-Tapia A.J. , Juarez-Vazquez C.I. , Holder-Espinasse M. , Manouvrier-Hanu S. , Escande F. , Barros-Nunez P.
Eur. J. Med. Genet.55:611-614(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN BDC
9.

"Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity."
Kotzsch A. , Nickel J. , Seher A. , Sebald W. , Muller T.D.
EMBO J.28:937-947(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 387-501 IN COMPLEX WITH MOUSE BMPR1B;FUNCTION;DISULFIDE BONDS
10.

"Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1."
Thomas J.T. , Kilpatrick M.W. , Lin K. , Erlacher L. , Lembessis P. , Costa T. , Tsipouras P. , Luyten F.P.
Nat. Genet.17:58-64(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AMDG TYR-400
11.

"Multiple synostosis type 2 (SYNS2) maps to 20q11.2 and caused by a missense mutation in the growth/differentiation factor 5 (GDF5)."
Akarsu A.N. , Rezaie T. , Demirtas M. , Farhud D.D. , Sarfarazi M.
Am. J. Hum. Genet.65:A281-A281(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYNS2 ASN-475
12.

"Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan syndrome)."
Faiyaz-Ul-Haque M. , Ahmad W. , Zaidi S.H.E. , Haque S. , Teebi A.S. , Ahmad M. , Cohn D.H. , Tsui L.-C.
Clin. Genet.61:454-458(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DPS PRO-441
13.

"Brachydactyly type C caused by a homozygous missense mutation in the prodomain of CDMP1."
Schwabe G.C. , Tuerkmen S. , Leschik G. , Palanduz S. , Stoever B. , Goecke T.O. , Mundlos S.
Am. J. Med. Genet. A124:356-363(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDC VAL-173
14.

"Du Pan syndrome phenotype caused by heterozygous pathogenic mutations in CDMP1 gene."
Szczaluba K. , Hilbert K. , Obersztyn E. , Zabel B. , Mazurczak T. , Kozlowski K.
Am. J. Med. Genet. A138:379-383(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DPS LEU-437 DEL; THR-439 AND LEU-440
15.

"Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2."
Seemann P. , Schwappacher R. , Kjaer K.W. , Krakow D. , Lehmann K. , Dawson K. , Stricker S. , Pohl J. , Ploeger F. , Staub E. , Nickel J. , Sebald W. , Knaus P. , Mundlos S.
J. Clin. Invest.115:2373-2381(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYM1B LEU-438;VARIANT BDA2 PRO-441;CHARACTERIZATION OF VARIANT SYM1B LEU-438;CHARACTERIZATION OF VARIANT BDA2 PRO-441
16.

"GDF5 is a second locus for multiple-synostosis syndrome."
Dawson K. , Seeman P. , Sebald E. , King L. , Edwards M. , Williams J. III , Mundlos S. , Krakow D.
Am. J. Hum. Genet.78:708-712(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYNS2 LEU-438
17.

"A novel mutation in GDF5 causes autosomal dominant symphalangism in two Chinese families."
Wang X. , Xiao F. , Yang Q. , Liang B. , Tang Z. , Jiang L. , Zhu Q. , Chang W. , Jiang J. , Jiang C. , Ren X. , Liu J.-Y. , Wang Q.K. , Liu M.
Am. J. Med. Genet. A140:1846-1853(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYM1B LYS-491
18.

"A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis."
Miyamoto Y. , Mabuchi A. , Shi D. , Kubo T. , Takatori Y. , Saito S. , Fujioka M. , Sudo A. , Uchida A. , Yamamoto S. , Ozaki K. , Takigawa M. , Tanaka T. , Nakamura Y. , Jiang Q. , Ikegawa S.
Nat. Genet.39:529-533(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO OSTEOARTHRITIS TYPE 5
19.

"Compound heterozygosity for GDF5 in Du Pan type chondrodysplasia."
Douzgou S. , Lehmann K. , Mingarelli R. , Mundlos S. , Dallapiccola B.
Am. J. Med. Genet. A146:2116-2121(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DPS GLN-378 AND THR-436
20.

"Brachydactyly type A2 associated with a defect in proGDF5 processing."
Ploeger F. , Seemann P. , Schmidt-von Kegler M. , Lehmann K. , Seidel J. , Kjaer K.W. , Pohl J. , Mundlos S.
Hum. Mol. Genet.17:1222-1233(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDA2 GLN-380;CHARACTERIZATION OF VARIANT BDA2 GLN-380
21.

"Novel point mutations in GDF5 associated with two distinct limb malformations in Chinese: brachydactyly type C and proximal symphalangism."
Yang W. , Cao L. , Liu W. , Jiang L. , Sun M. , Zhang D. , Wang S. , Lo W.H. , Luo Y. , Zhang X.
J. Hum. Genet.53:368-374(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYM1B ARG-373;CHARACTERIZATION OF VARIANT SYM1B ARG-373
22.

"Mutations in GDF5 presenting as semidominant brachydactyly A1."
Byrnes A.M. , Racacho L. , Nikkel S.M. , Xiao F. , MacDonald H. , Underhill T.M. , Bulman D.E.
Hum. Mutat.31:1155-1162(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDA1C CYS-399;CHARACTERIZATION OF VARIANT BDA1C CYS-399

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